Curcumin, a major component of turmeric is widely used in curry spices were able to suppress cell signaling pathways that encourage cancer growth in head and neck cancer. Curcumin can work in the mouth of patients with malignant head and neck cancer, and reduce cancer growth.
"Not only affects cancer cells by inhibiting the signal pathway, curcumin also affect saliva by reducing cytokine enzyme, which causes inflammation present in saliva,"
Turmeric is a spice that is widely used in South Asia, East Asia, and Central Asia for cooking and has long been known to have medicinal properties, which have anti-inflammatory properties.
Previous studies have shown that curcumin can suppress the growth of certain cancers. For years, women in India have used turmeric as a topical anti-aging medicine, treat cramps during menstruation and as a poultice on the skin to speed healing of wounds.
Curcumin suppresses the growth of head and neck cancer in mice. In animal studies, curcumin is applied directly to the tumor in the form of pasta. Research in 2010 which is also done on mouse cells found that curcumin suppresses the growth of head and neck cancer by regulating cell cycle, "
Curcumin binds to and prevents an enzyme known as an inhibitor of kappa β kinase (IKK) which promotes cancer growth. In this study, 21 patients with head and neck cancer gave saliva samples before and after they chewed two tablets of 1,000 milligrams of curcumin. An hour later, the saliva sample was taken and extracted for measuring protein kinase activity of IKKβ.
Eating curcumin not only make contact with the cancer, but also with saliva, and this research shows that it reduces the levels of cytokines in exacerbating cancer.
"An independent laboratory in Maryland confirmed that the cytokines in saliva promote inflammation and help to feed the cancer. However, the cytokine reduced in patients who chew and curcumin inhibits cell signaling pathways that trigger cancer growth,"
Curcumin has a significant inhibitory effect, blocking the two triggers the growth of cancers of the head and neck cancers are different. The researchers believe that curcumin may be combined with other treatments such as chemotherapy and radiation to treat head and neck cancer. It can also be given to patients at high risk for head and neck cancer, ie smokers, those who like to chew tobacco, and patients with HPV infection.
To be effective in fighting cancer, curcumin should be used in supplement form. Although turmeric is used in cooking, the amount of curcumin is required to produce a much greater clinical effect. "Expecting a positive effect through eating foods spiced with turmeric is not realistic,"
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